Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer

Lung cancer is a serious disease and the leading cause of cancer-related death. Metal-phenolic network nanoparticles have been proposed as a promising strategy for cancer therapy. In this work, eight-arm PEG succinimidyl glutarate, copper ions and doxorubicin (DOX) were integrated into one nanoparticle via hydrophobic interactions and coordination interactions to achieve chemotherapy (CT) and chemodynamic therapy (CDT). [email protected] accumulated in tumour tissue and released DOX and Cu2+ into the tumour microenvironment. Cu2+ reacted with GSH to form Cu+. Cu+ continued to react with H2O2 to form •OH. DOX killed lung cancer cells and activated NOX4, up-regulating the endogenous H2O2 level and further enhancing the efficiency of CDT. In vitro and in vivo experiments demonstrated that [email protected] has superior biological safety and can inhibit the growth of lung cancer tumours via synergistic CT/CDT. This research offers a new strategy for the construction of metal-phenolic network nanoparticles for the synergistic treatment of lung cancer by CT/CDT.