恩扎鲁胺
前列腺癌
转录组
生物
雄激素受体
醋酸阿比特龙酯
癌症研究
基因表达谱
刺猬
雄激素
PTEN公司
癌症
肿瘤科
内科学
基因
遗传学
医学
基因表达
雄激素剥夺疗法
内分泌学
信号转导
PI3K/AKT/mTOR通路
激素
作者
Naoual Menssouri,Loïc Poiraudeau,Carole Hélissey,Ludovic Bigot,Jonathan Sabio,Tony Ibrahim,Cédric Pobel,Claudio Nicotra,Maud Ngo‐Camus,Ludovic Lacroix,Étienne Rouleau,Lambros Tselikas,Anne Chauchereau,Félix Blanc‐Durand,Alice Bernard‐Tessier,Anna Patrikidou,Natacha Naoun,Ronan Flippot,Émeline Colomba,Alina Fuerea
标识
DOI:10.1158/1078-0432.ccr-22-3736
摘要
Low AR activity, activation of stemness programs, and Hedgehog pathway were associated with primary ARPIs' resistance, whereas most acquired resistance was associated with subclonal evolution, AR-related events, and neuroendocrine differentiation. See related commentary by Slovin, p. 4323.
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