iMPI: portable human-sized magnetic particle imaging scanner for real-time endovascular interventions

磁粉成像 透视 计算机科学 扫描仪 数字减影血管造影 软件可移植性 放射科 医学物理学 医学 血管造影 人工智能 磁性纳米粒子 物理 纳米颗粒 程序设计语言 量子力学
作者
Patrick Vogel,Martin Rückert,C. Greiner,Jillian R. Gunther,Tobias Reichl,Thomas Kampf,Thorsten Alexander Bley,Volker C. Behr,Stefan Herz
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:13 (1) 被引量:15
标识
DOI:10.1038/s41598-023-37351-2
摘要

Minimally invasive endovascular interventions have become an important tool for the treatment of cardiovascular diseases such as ischemic heart disease, peripheral artery disease, and stroke. X-ray fluoroscopy and digital subtraction angiography are used to precisely guide these procedures, but they are associated with radiation exposure for patients and clinical staff. Magnetic Particle Imaging (MPI) is an emerging imaging technology using time-varying magnetic fields combined with magnetic nanoparticle tracers for fast and highly sensitive imaging. In recent years, basic experiments have shown that MPI has great potential for cardiovascular applications. However, commercially available MPI scanners were too large and expensive and had a small field of view (FOV) designed for rodents, which limited further translational research. The first human-sized MPI scanner designed specifically for brain imaging showed promising results but had limitations in gradient strength, acquisition time and portability. Here, we present a portable interventional MPI (iMPI) system dedicated for real-time endovascular interventions free of ionizing radiation. It uses a novel field generator approach with a very large FOV and an application-oriented open design enabling hybrid approaches with conventional X-ray-based angiography. The feasibility of a real-time iMPI-guided percutaneous transluminal angioplasty (PTA) is shown in a realistic dynamic human-sized leg model.
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