Family history and genetic risk score combined to guide cancer risk stratification: A prospective cohort study

医学 前列腺癌 癌症 结直肠癌 内科学 危险系数 家族史 置信区间 乳腺癌 肿瘤科 前瞻性队列研究 队列 癌症登记处 相对风险 人口学 社会学
作者
Ji Chen,Wenjing Ge,Chen Zhu,Fang Shen,Yuhui Yu,Guanlian Pang,Qiao Li,Mingxuan Zhu,Zhimin Ma,Xia Zhu,Yating Fu,Linnan Gong,Tianpei Wang,Lingbin Du,Guangfu Jin,Meng Zhu
出处
期刊:International Journal of Cancer [Wiley]
标识
DOI:10.1002/ijc.35187
摘要

Abstract Family history (FH) of cancer and polygenic risk scores (PRS) are pivotal for cancer risk assessment, yet their combined impact remains unclear. Participants in the UK Biobank (UKB) were recruited between 2006 and 2010, with complete follow‐up data updated until February 2020 for Scotland and January 2021 for England and Wales. Using UKB data ( N = 442,399), we constructed PRS and incidence‐weighted overall cancer PRS (CPRS). FH was assessed through self‐reported standardized questions. Among 202,801 men (34.6% with FH) and 239,598 women (42.0% with FH), Cox regression was used to examine the associations between FH, PRS, and cancer risk. We found a significant dose–response relationship between FH of cancer and corresponding cancer risk ( P trend < .05), with over 10 significant pairs of cross‐cancer effects of FH. FH and PRS are positively correlated and independent. Joint effects of FH of cancer (multiple cancers) and PRS (CPRS) on corresponding cancer risk were observed: for instance, compared with participants with no FH of cancer and low PRS, men with FH of cancer and high PRS had the highest risk of colorectal cancer (hazard ratio [HR]: 3.69, 95% confidence interval [CI]: 3.01–4.52). Additive interactions were observed in prostate and overall cancer risk for men and breast cancer for women, with the most significant result being a relative excess risk of interaction (RERI) of 2.98, accounting for ~34% of the prostate cancer risk. In conclusion, FH and PRS collectively contribute to cancer risk, supporting their combined application in personalized risk assessment and early intervention strategies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
杨乐多完成签到,获得积分10
刚刚
量子星尘发布了新的文献求助10
刚刚
李健应助大帅采纳,获得10
1秒前
2秒前
冷艳的火龙果完成签到,获得积分10
2秒前
不知完成签到 ,获得积分10
2秒前
Zard发布了新的文献求助10
4秒前
清仔发布了新的文献求助10
4秒前
5秒前
大地上的鱼完成签到,获得积分10
5秒前
5秒前
上官若男应助平常的路人采纳,获得10
5秒前
小花发布了新的文献求助10
6秒前
庸俗完成签到,获得积分10
7秒前
8秒前
论文顺利发布了新的文献求助10
8秒前
8秒前
砚行书完成签到,获得积分10
8秒前
CodeCraft应助Qsss采纳,获得10
8秒前
情怀应助葫芦娃采纳,获得10
9秒前
小慈爱鸡完成签到 ,获得积分10
9秒前
ttelsa完成签到,获得积分10
9秒前
年轻小之完成签到 ,获得积分10
9秒前
9秒前
snowdream发布了新的文献求助10
10秒前
xiaoying完成签到,获得积分10
10秒前
12秒前
大帅发布了新的文献求助10
12秒前
深情丸子发布了新的文献求助10
12秒前
通通真行完成签到,获得积分10
13秒前
15秒前
JamesPei应助科研通管家采纳,获得10
15秒前
科研通AI2S应助科研通管家采纳,获得10
15秒前
英姑应助科研通管家采纳,获得10
15秒前
研友_VZG7GZ应助科研通管家采纳,获得10
15秒前
脑洞疼应助科研通管家采纳,获得10
16秒前
爆米花应助科研通管家采纳,获得10
16秒前
乐乐应助科研通管家采纳,获得10
16秒前
乐乐应助科研通管家采纳,获得10
16秒前
李健应助科研通管家采纳,获得10
16秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048