No In Vivo Evidence for Estrogen Receptor Density Changes in Human Neuroendocrine Aging or Their Relationship to Cognition and Menopausal Symptoms

TO THE EDITOR: A recent paper by Mosconi et al. ([1][1]) reports an in vivo brain 18F-fluoroestradiol (18F-FES) PET study of healthy midlife women, purportedly revealing progressively higher estrogen receptor (ER) density over the menopause transition in estrogen-regulated networks. According to