端粒酶
端粒
药物发现
小分子
计算生物学
寡核苷酸
癌症
生物
生物信息学
遗传学
DNA
基因
作者
Lauren Kageler,Elisa Aquilanti
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2024-08-28
卷期号:52 (4): 1957-1968
摘要
Telomerase, crucial for maintaining telomere length, is an attractive target for cancer therapy due to its role in cellular immortality. Despite three decades of research efforts, no small-molecule telomerase inhibitors have been clinically approved, highlighting the extensive challenges in developing effective telomerase-based therapeutics. This review examines conventional and emerging methods to measure telomerase activity and discusses existing inhibitors, including oligonucleotides and small molecules. Furthermore, this review highlights recent breakthroughs in structural studies of telomerase using cryo-electron microscopy, which can facilitate improved structure-based drug design. Altogether, advancements in structural methodologies and high-throughput screening offer promising prospects for telomerase-based cancer therapeutic development.
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