危险系数
腺癌
医学
置信区间
内科学
淋巴细胞
肿瘤科
肺
病理
癌症
作者
Xipeng Pan,Huan Lin,Zaiyi Liu,Li‐Xu Yan,Yumeng Wang,Bingbing Li,Entao Liu,Chu Han,Zhenwei Shi,Cheng Lu,Zhenbing Liu,Cheng Pang,Zhenhui Li,Yanfen Cui,Xipeng Pan,Xin Chen
标识
DOI:10.1016/j.cmpb.2023.107617
摘要
A high degree of lymphocyte infiltration is related to superior outcomes amongst patients with lung adenocarcinoma. Recent evidence indicates that the spatial interactions between tumours and lymphocytes also influence the anti-tumour immune responses, but the spatial analysis at the cellular level remains insufficient. We proposed an artificial intelligence-quantified Tumour-Lymphocyte Spatial Interaction score (TLSI-score) by calculating the ratio between the number of spatial adjacent tumour-lymphocyte and the number of tumour cells based on topology cell graph constructed using H&E-stained whole-slide images. The association of TLSI-score with disease-free survival (DFS) was explored in 529 patients with lung adenocarcinoma across three independent cohorts (D1, 275; V1, 139; V2, 115). After adjusting for pTNM stage and other clinicopathologic risk factors, a higher TLSI-score was independently associated with longer DFS than a low TLSI-score in the three cohorts [D1, adjusted hazard ratio (HR), 0.674; 95% confidence interval (CI) 0.463–0.983; p = 0.040; V1, adjusted HR, 0.408; 95% CI 0.223–0.746; p = 0.004; V2, adjusted HR, 0.294; 95% CI 0.130–0.666; p = 0.003]. By integrating the TLSI-score with clinicopathologic risk factors, the integrated model (full model) improves the prediction of DFS in three independent cohorts (C-index, D1, 0.716 vs. 0.701; V1, 0.666 vs. 0.645; V2, 0.708 vs. 0.662) TLSI-score shows the second highest relative contribution to the prognostic prediction model, next to the pTNM stage. TLSI-score can assist in the characterising of tumour microenvironment and is expected to promote individualized treatment and follow-up decision-making in clinical practice.
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