癌症
转移
癌症干细胞
癌细胞
癌症研究
间充质干细胞
透明质酸
下调和上调
化学
医学
病理
内科学
乳腺癌
生物化学
基因
解剖
作者
Yutong Zhu,Xi Deng,Zideng Dai,Qing Liu,Yichen Kuang,Tianzhi Liu,Hangrong Chen
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-06-17
卷期号:24 (26): 8179-8188
标识
DOI:10.1021/acs.nanolett.4c02192
摘要
The unique "Iron Addiction" feature of cancer stem cells (CSCs) with tumorigenicity and plasticity generally contributes to the tumor recurrence and metastasis after a lumpectomy. Herein, a novel "Ferroptosis Amplification" strategy is developed based on integrating gallic acid-modified FeOOH (GFP) and gallocyanine into Pluronic F-127 (F127) and carboxylated chitosan (CC)-based hydrogel for CSCs eradication. This "Ferroptosis Amplifier" hydrogel is thermally sensitive and achieves rapid gelation at the postsurgical wound in a breast tumor model. Specifically, gallocyanine, as the Dickkopf-1 (DKK1) inhibitor, can decrease the expression of SLC7A11 and GPX4 and synergistically induce ferroptosis of CSCs with GFP. Encouragingly, it is found that this combination suppresses the migratory and invasive capability of cancer cells
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