病毒
爱泼斯坦-巴尔病毒
生物
病毒学
爱泼斯坦-巴尔病毒感染
癌症研究
计算生物学
作者
Samantha S. Soldan,Troy E. Messick,Paul M. Lieberman
标识
DOI:10.1016/j.coviro.2022.101260
摘要
Epstein–Barr virus (EBV) establishes a lifelong latent infection that can be a causal agent for a diverse spectrum of cancers and autoimmune disease. A complex and dynamic viral lifecycle evades eradication by the host immune system and confounds antiviral therapeutic strategies. To date, there are no clinically approved vaccines or therapies that selectively target EBV as the underlying cause of EBV-associated disease. Here, we review the challenges and recent advances in the development of EBV-specific therapeutics for treatment of EBV-associated cancers.
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