Reducing design and operational margin is a key factor that makes fabricated chips competitive in terms of speed and power consumption. On the other hand, a smaller margin involves a higher risk that a timing error occurs in field. This paper proposes a stochastic framework that estimates timing error rate under static process variations and dynamic environmental variations for circuits with and without run-time adaptive speed control. The proposed framework extends the state assignment of the continuous-time Markov process used in the previous work so as to take into account within-die random variation, and speeds up the database construction for the transition rate matrix by combining logic simulation and statistical static timing analysis. This paper also demonstrates that the proposed framework can cope with transistor-by-transistor stochastic aging processes. Experimental results show that the within-die random variation deviates the MTTF with σ of 52%. The CPU time for the transition rate matrix computation is reduced to 1/30.