编配
免疫系统
淋巴系统
生物
免疫学
细胞生物学
艺术
音乐剧
视觉艺术
作者
Jun Kunisawa,Satoru Fukuyama,Hiroshi Kiyono
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2005-09-01
卷期号:5 (6): 557-572
被引量:61
标识
DOI:10.2174/1566524054863924
摘要
As inductive tissues for the initiation of antigen-specific T and B cell responses, the various mucosa-associated lymphoid tissues (MALT) of the aerodigestive tract, which include gut-associated lymphoid tissue (GALT), nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT), share many histological and immunological characteristics. However, recent advances in our molecular and cellular understanding of immunological development have revealed that the various types of MALT also exhibit different molecular and cellular interactions for their organogenesis. In this review, we delineate the distinctive features of GALT, NALT and BALT and seek to show the role played by those features in the regulation of mucosal tissue organogenesis, the mucosal immune system, and mucosal homeostasis, all in an attempt to provide insights which might lead to a prospective mucosal vaccine.
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