Claisen Rearrangement of Aliphatic Allyl Vinyl Ethers from 1912 to 2012: 100 Years of Electrophilic Catalysis

This review summarizes, from a personal perspective, the development of catalytic asymmetric Claisen rearrangements from 1912 to 2012. 1 Introduction 2 Gosteli–Claisen Rearrangement 3 Claisen Rearrangement Using Stable Enols: Kojic Acid and Diosphenols 4 The Early Years: Catalysis by Brønsted Acids 5 Lewis Acid Mediated Claisen Rearrangements: The Aluminum Age 6 Catalysis by Precious Metals 7 Catalysis by σ-Lewis Acids 8 Catalysis by Achiral Organocatalysts 9 Catalytic Asymmetric Claisen Rearrangements 10 Conclusion