坏死性下垂
骨关节炎
炎症
发病机制
医学
软骨
程序性细胞死亡
疾病
关节软骨
关节病
机制(生物学)
激酶
癌症研究
免疫学
生物信息学
细胞凋亡
病理
生物
细胞生物学
解剖
遗传学
替代医学
哲学
认识论
作者
Zhichao Liu,Zhouyang Qian,Yingnan Wang,Hui-Ming Wang
标识
DOI:10.3724/zdxbyxb-2021-0402
摘要
Osteoarthritis is a progressive degenerative joint disease induced by many causes, for which there is no radical cure currently. Necroptosis is a newly reported programmed cell death, and its related factors are also inseparable from the progress of osteoarthritis. For examples, damage-associated molecular pattern promotes the release of various inflammatory factors, so as to recruit macrophages and promote local inflammation of the joint; inhibition of receptor-interacting protein kinase can reduce the death of cell and the expression of inflammatory factors, so as to reduce cartilage damage. Therefore, in-depth study of the regulatory mechanism of necroptosis in osteoarthritis will help to further reveal the pathogenesis of osteoarthritis, so as to provide potential targets for the treatment of osteoarthritis.
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