材料科学
抗菌活性
金黄色葡萄球菌
胶粘剂
复合材料
伤口愈合
共聚物
抗氧化剂
伤口敷料
纳米技术
生物医学工程
化学
聚合物
细菌
医学
生物化学
生物
外科
图层(电子)
遗传学
作者
Yanyan Li,Peng Yu,Jie Wen,Hui Sun,Dingqian Wang,Lei Zhu,Jianshu Li,Hetao Chu
标识
DOI:10.1002/adfm.202110720
摘要
Abstract Wound healing in movable parts including joints and neck remains a critical challenge due to frequent motions and poor flexibility of dressing which may lead to mismatching of mechanical properties and poor fitting between dressings and wounds, thus increasing the risk of bacterial infection and inflammation. Herein, through the copolymerization of N ‐isopropylacrylamide, acrylamide, and acryloyl Pluronic 127 (PF127‐DA), and functionalization by molybdenum disulfide‐polydopamine nanozyme (MP), a new type of stretchable, adhesive, and low hysteretic MP composite hydrogel (MPH) with antibacterial and antioxidant dual functions for closely fitting and wound healing in movable parts is designed. The excellent mechanical properties (stretching about 616%, hysteresis about 0.17) and adhesiveness (about 3.25 kPa) of MPH make it fast to match the motions of the movable parts, close to fit with wound resisting bacterial invasion, and effective to avoid secondary dressing fixation. Furthermore, the dual functions of antibacterial derived from photothermal properties and antioxidant derived from intrinsic enzyme‐like activity can eliminate the infection (exposing to 808 nm irradiation, the killing ratios for Staphylococcus aureus and Escherichia coli are 99.1% and 93.9%), reduce oxidative stress, improve wound microenvironment, and promote wound healing.
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