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Immune Cell Populations in the Duodenal Mucosa of Cats with Inflammatory Bowel Disease

固有层 医学 病理 炎症性肠病 十二指肠 肠粘膜 免疫系统 地穴 免疫球蛋白A 免疫学 胃肠病学 内科学 免疫球蛋白G 疾病 上皮
作者
Nashwa Waly,Christopher Stokes,Tim Gruffydd-Jones,Michael Day
出处
期刊:Journal of Veterinary Internal Medicine [Wiley]
卷期号:18 (6): 816-825 被引量:44
标识
DOI:10.1111/j.1939-1676.2004.tb02627.x
摘要

The aim of this study was to characterize the phenotype of leukocytes infiltrating the duodenal mucosa of cats with inflammatory bowel disease (IBD) by using immunohistochemistry and computer‐aided morphometry to assess whether immunologic markers would aid in characterization of IBD. Frozen and formalin‐fixed duodenal biopsies were collected from cats referred for investigation of chronic vomiting, diarrhea, or both (n = 34). Reference ranges were previously established by using duodenal samples from healthy cats (n = 16). No significant difference was found in the number of immunoglobulin G+ (IgG+) or IgA+ in either the villous lamina propria or the crypt lamina propria between cats with IBD and control cats. T cells (CD3+) increased in number from crypt to the tip of the villi in biopsies from both diseased (mean ± SD for each group was 18.8±6.6 and 17.7±4.2 cells/10,000μm 2 in cryptal areas to 25.2±9.5 and 29.1±13.3 cells/10,000μm 2 in villous areas) and healthy animals (17.9±3.9 cells/10,000μm 2 in cryptal areas to 24.1±9.3 cells/10,000μm 2 in villous areas) and no significant difference was found between diseased and control cats. By contrast, major histocompatibility complex (MHC) class II expression by leukocytes with dendritic cell or macrophage morphology in the lamina propria was significantly greater in cats with IBD (13.3±4.2 cells/10,000μm 2 in cryptal area; P = .016) than in healthy cats (11.9±3.0 cells/10,000μm 2 ) and MHC class II expression by enterocytes also was more pronounced in these cats showing an overall intensity of expression of 7.1±4.0 cells/10,000μm 2 in cats with IBD as opposed to 0.0±0.0 cells/10,000μm 2 to 0.3±0.7 cells/10,000μm 2 in healthy cats. These findings suggest that a subtle immunologic dysregulation occurs in spontaneously arising feline IBD.
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