蛋白质组学
药物发现
计算生物学
鉴定(生物学)
生物标志物发现
功能(生物学)
计算机科学
生物信息学
化学
生物
生物化学
植物
进化生物学
基因
作者
Felix Meissner,Jennifer Geddes‐McAlister,Matthias Mann,Marcus Bantscheff
标识
DOI:10.1038/s41573-022-00409-3
摘要
Proteins are the main targets of most drugs; however, system-wide methods to monitor protein activity and function are still underused in drug discovery. Novel biochemical approaches, in combination with recent developments in mass spectrometry-based proteomics instrumentation and data analysis pipelines, have now enabled the dissection of disease phenotypes and their modulation by bioactive molecules at unprecedented resolution and dimensionality. In this Review, we describe proteomics and chemoproteomics approaches for target identification and validation, as well as for identification of safety hazards. We discuss innovative strategies in early-stage drug discovery in which proteomics approaches generate unique insights, such as targeted protein degradation and the use of reactive fragments, and provide guidance for experimental strategies crucial for success.
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