斑秃
杜皮鲁玛
医学
皮肤病科
免疫学
脱发
毛囊
免疫失调
白细胞介素23
乌斯特基努马
细胞因子
免疫系统
白细胞介素
特应性皮炎
内科学
肿瘤坏死因子α
英夫利昔单抗
作者
Peng Jin,Wei Li,Qinqin Zhang,Tingting Gao,Jianxue Bai,Dong Liang,Lili Zhi
摘要
Alopecia areata (AA), which is a common and inflammatory hair loss and one of the most frequent dermatological conditions with higher incidence worldwide, the complex interplay involved multiple factors was contributed to the pathogenesis that consists of immune privilege losing and destruction with autoimmune-mediated in hair follicle also the abnormal regulation of inflammatory pathways was highlighted, although it was remained unclear to date.(J Am Acad Dermatol, 78, 2018, 1) Some treatment options for AA were proposed with great advances in recent years, but the options and efficacy were limited, such as platelet-rich plasma, JAK-STAT inhibitor, PDE4 inhibitor, and others, also the good response with regrow hair of cytokine-targeted therapy like dupilumab, ustekinumab was shown.(Clin Exp Med, 21, 2021, 215; Drugs, 80, 2020, 635) Here, we present a case with onset of AA following dupilumab treatment, the chronological relationship between the AA onset and dupilumab use should be known and emphasized.
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