Dialkyl aluminium chloride: a reagent for removal of trityl group from trityl ethers of deoxynucleosides, deoxynucleotides, and oligodeoxynucleotides

Detritylation of N-acyl-5′-o-tritylated deoxynucleosides, deoxynucleotides, and oligodeoxynucleotides have been quantitatively achieved in minutes at room temperature by using diethylaluminium chloride or diisobutylaluminium chloride. Reactions take place in unpolar solvents in homogeneous phase under completely aprotic conditions.