摘要
HepatologyVolume 27, Issue 6 p. 1463-1466 Concise ReviewFree Access Hepatic steatosis: Innocent bystander or guilty party? Christopher P. Day Ph.D., M.D., Corresponding Author Christopher P. Day Ph.D., M.D. Centre for Liver Research, Floor 4, William Leech Building Medical School, Framlington Place, Newcastle upon Tyne, UKCentre for LiverResearch, Floor 4, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH UK. Fax: 44-191-222-0723===Search for more papers by this authorOliver F.W. James, Oliver F.W. James Centre for Liver Research, Floor 4, William Leech Building Medical School, Framlington Place, Newcastle upon Tyne, UKSearch for more papers by this author Christopher P. Day Ph.D., M.D., Corresponding Author Christopher P. Day Ph.D., M.D. Centre for Liver Research, Floor 4, William Leech Building Medical School, Framlington Place, Newcastle upon Tyne, UKCentre for LiverResearch, Floor 4, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH UK. Fax: 44-191-222-0723===Search for more papers by this authorOliver F.W. James, Oliver F.W. James Centre for Liver Research, Floor 4, William Leech Building Medical School, Framlington Place, Newcastle upon Tyne, UKSearch for more papers by this author First published: 30 December 2003 https://doi.org/10.1002/hep.510270601Citations: 302AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Day CP, Yeaman SJ. The biochemistry of alcoholic fatty liver. Biochim Biophys Acta 1994; 1215: 33–48. 2 Fromenty B, Pessayre D. Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther 1995; 67: 101–154.MEDLINE 3 Sherlock S. Acute fatty liver of pregnancy and the microvesicular fat diseases. Gut 1983; 24: 265–269.MEDLINE 4 Sherlock S. Alcoholic liver disease. Lancet 1995; 345: 227–229.MEDLINE 5 Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103–1109.MEDLINE 6 Sorensen TIA, Orholm M, Bentsen KD, Hoybye G, Eghoje K, Christoffersen P. Lancet 1984; 2: 241–244.MEDLINE 7 Teli MR, Day CP, Burt AD, Bennett MK, James OFW. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 1995; 346: 987–990.MEDLINE 8 Reeves HL, Burt AD, Wood S, Day CP. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis. J Hepatol 1996; 25: 677–683.MEDLINE 9 Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990; 12: 1106–1110.MEDLINE 10 Lieber CS. Alcohol and the liver: 1994 update. Gastroenterology 1994; 106: 1085–1105.MEDLINE 11 Diehl AM, Goodman Z, Ishak KG. Alcohollike liver disease in nonalcoholics. Gastroenterology 1988; 95: 1056–1062.MEDLINE 12 Day CP. Is necroinflammation a prerequisite for fibrogenesis? Hepatogastroenterol 1996; 43: 104–120. 13 Nanji AA, Zhao S, Sardrzadeh SMH, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome P4502E1 induction and lipid peroxidation is associated with severe injury in fish oil-treated ethanol-fed rats. Alcohol Clin Exp Res 1994; 18: 1280–1285.MEDLINE 14 Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M, French SW. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats fed intragastrically fed with ethanol. Hepatology 1996; 23: 155–163.MEDLINE 15 Curzio M, Esterbauer H, Dianzani MU. Chemotactic activity of hydroxyalkenals on rat neutrophils. Int J Tiss Reac 1985; 7: 137–142. 16 Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995; 96: 2461–2468.MEDLINE 17 Tsukamoto H, Horne W, Kamimura S, Niemela O, Parkkila S, Yla-Herttuala S, Brittenham G. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995; 96: 620–630.MEDLINE 18 Paradis V, Kollinger M, Fabre M, Holstege A, Poynard T, Bedossa P. In situ detection of lipid peroxidation by-products in chronic liver diseases. Hepatology 1997; 26: 135–142.MEDLINE 19 Letteron P, Fromenty B, Terris B, Degott C, Pessayre D. Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice. J Hepatol 1996; 24: 200–208.MEDLINE 20 Weltmann MD, Liddle C, Farrell GC. Evidence that oxidative stress plays a role in steatohepatitis produced in a rat nutritional model [Abstract]. Hepatology 1996; 24: 240A. 21 Pinto HC, Felipe P, Baptista A, Fernandes A, Camilo E, Ramalho F, Moura MC. Hepatic steatosis and lipid peroxidation in human chronic liver diseases [Abstract]. Hepatology 1996; 24: 311A. 22 Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C. Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis. Hepatology 1998; 27: 128–133.MEDLINE 23 Weltman MD, Farrell GC, Liddle C. Increased CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 1996; 111: 1645–1653.MEDLINE 24 Zangar RC, Novak RF. Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes. Arch Biochem Biophys 1997; 337: 217–224.MEDLINE 25 Osmundsen H, Bremer J, Pedersen JI. Metabolic aspects of peroxisomal β-oxidation. Biochim Biopys Acta 1991; 1085: 141–158. 26 George DK, Goldwurm S, Macdonald GA, Cowley LL, Walker NI, Ward PJ, Jazwinska EC, et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 1998; 114: 311–318.MEDLINE 27 Cotrim HP, Parana R, Portugal M, Lyra L, Andrade Z, Freitas LAR. Nonalcoholic steatohepatitis (NASH) and industrial toxins. Follow up of patients removed from one industrial area [Abstract]. Hepatology 1997; 26: 149A. 28 McClain CJ, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis 1993; 13: 170–182.MEDLINE 29 Haines NW, Baker AL, Boyer JL, Glagov S, Schneir H, Jaspan J, Ferguson DJ. Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: a prospective study. Hepatology 1981; 1: 161–165.MEDLINE 30 Drenick EJ, Fisler J, Johnson D. Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazole irrespective of protein-calorie malnutrition. Gastroenterology 1982; 82: 534–548. 31 Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci U S A 1997; 94: 2557–2562.MEDLINE 32 Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss and relationship to lipoprotein lipase. J Clin Invest 1995; 95: 2111–2119.MEDLINE 33 Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science 1996; 271: 665–668.MEDLINE 34 Yamakawa T, Tanaka S-I, Yamakawa Y, Kiuchi Y, Isoda F, Kawamoto S, Sokuda K, et al. Augmented production of tumor necrosis factor-alpha in obese mice. Immunol Immunopathol 1995; 75: 51–56. 35 Fromenty B, Grimbert S, Mansouri A, Beaugrand M, Erlinger S, Rotig A, Pessayre D. Hepatic mitochondrial DNA deletion in alcoholics: association with microvesicular steatosis. Gastroenterology 1995; 108: 193–200.MEDLINE 36 DiLuzio NR, Costales F. Inhibition of ethanol and carbon tetrachloride induced fatty liver by antoxidants. Exp Mol Pathol 1965; 4: 141–154. 37 Letteron P, Duchatelle V, Berson A, Fromenty B, Fisch C, Degott C, Benhamou JP, et al. Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers. Gut 1993; 34: 409–414.MEDLINE 38 Jaeschke H, Wang Y, Essani NA. Reactive oxygen species activate the transcription factor NF-KB in the liver by induction of lipid peroxidation [Abstract]. Hepatology 1996; 24: 238A. 39 Caraceni P, Ryu HS, Subbotin V, De Maria N, Colantoni A, Roberts L, Trevisani F, et al. Rat hepatocytes isolated from alcohol-induced fatty liver have an increased sensitivity to anoxic injury. Hepatology 1997; 25: 943–949.MEDLINE 40 Trevisani F, Colantoni A, Caraceni P, Van Thiel DH. The use of donor fatty liver for liver transplantation: a challenge or a quagmire? J Hepatol 1996; 24: 114–121.MEDLINE Citing Literature Volume27, Issue6June 1998Pages 1463-1466 ReferencesRelatedInformation