Pathological fractures are defined as fractures, which appear at diseased and mechanically weakened bones due to systemic or local processes. Their frequency is below 5%. This study demonstrates typical results and diagnostic criteria of pathological fractures. It will be shown, how diagnostic analysis is supposed to be performed to recognize pathological fractures. Based just on the X-ray image, diagnostic algorithms should provide all tools required for the radiologist to create a final diagnosis or to refer to other appropriate imaging modalities followed by a correct diagnosis and, if necessary, to allow interdisciplinary causal therapies.