衍生化
化学
色谱法
质谱法
试剂
选择性
液相色谱-质谱法
代谢物
高效液相色谱法
有机化学
催化作用
生物化学
作者
Bao-Ling Qi,Ping Liu,Qiu-Yi Wang,Wen‐Jing Cai,Bi‐Feng Yuan,Yu‐Qi Feng
标识
DOI:10.1016/j.trac.2014.03.013
摘要
Liquid chromatography-mass spectrometry (LC-MS) is one of the most prominent analytical techniques, due to its inherent selectivity and sensitivity. In LC-MS, chemical derivatizations are frequently used to enhance the MS ionization efficiency and selectivity, to facilitate structure elucidation, and to improve the chromatographic separation. In this review, we present an overview of derivatization-based LC-MS analysis. We summarize the reaction mechanisms of representative derivatization reagents and the selection strategy to guide and to stimulate future studies. Furthermore, we emphasize applications of derivatization in peptide and protein analysis, metabolite analysis, environmental analysis, pharmaceutical analysis, food-safety evaluation and MS imaging.
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