免疫球蛋白超家族
受体
生物
自然杀伤细胞
分子生物学
跨膜蛋白
抗体
跨膜结构域
细胞表面受体
细胞
细胞生物学
细胞毒性
生物化学
免疫学
体外
作者
Claudia Cantoni,Cristina Bottino,Massimo Vitale,A. Pessino,Raffaella Augugliaro,Angela Malaspina,Silvia Parolini,Lorenzo Moretta,Lorenzo Moretta,Roberto Biassoni
标识
DOI:10.1084/jem.189.5.787
摘要
Surface receptors involved in natural killer (NK) cell triggering during the process of tumor cell lysis have recently been identified. Of these receptors, NKp44 is selectively expressed by IL-2– activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Here we describe the molecular cloning of NKp44. Analysis of the cloned cDNA indicated that NKp44 is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The charged amino acid lysine in the transmembrane region may be involved in the association of NKp44 with the signal transducing molecule killer activating receptor–associated polypeptide (KARAP)/DAP12. These molecules were found to be crucial for the surface expression of NKp44. In agreement with data of NKp44 surface expression, the NKp44 transcripts were strictly confined to activated NK cells and to a minor subset of TCR-γ/δ+ T lymphocytes. Unlike genes coding for other receptors involved in NK cell triggering or inhibition, the NKp44 gene is on human chromosome 6.
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