Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology

活产 辅助生殖技术 怀孕 产科 体质指数 医学 生育率 妇科 人口 生物 不育 内科学 遗传学 环境卫生
作者
Hassan W. Bakos,Richard C. Henshaw,Megan Mitchell,Michelle Lane
出处
期刊:Fertility and Sterility [Elsevier]
卷期号:95 (5): 1700-1704 被引量:195
标识
DOI:10.1016/j.fertnstert.2010.11.044
摘要

ObjectiveTo determine the relationship between paternal body mass index (BMI), embryo development and pregnancy, and live birth outcomes after assisted reproductive technology (ART).DesignRetrospective analysis of ART cycles.SettingMajor assisted reproduction center.Patient(s)Three hundred five couples undergoing ART in a private fertility clinic.Intervention(s)No intervention was undertaken in patients involved in this study.Main Outcome Measure(s)Live birth outcomes and clinical pregnancy rates.Result(s)No significant relationship between paternal BMI and early embryo development was found. However, increased paternal BMI was associated with decreased blastocyst development, clinical pregnancy rates and live birth outcomes.Conclusion(s)To our knowledge, this is the first report linking increased paternal BMI and clinical pregnancy and live birth rates after ART treatment. Further work to elucidate the mechanisms involved is required. To determine the relationship between paternal body mass index (BMI), embryo development and pregnancy, and live birth outcomes after assisted reproductive technology (ART). Retrospective analysis of ART cycles. Major assisted reproduction center. Three hundred five couples undergoing ART in a private fertility clinic. No intervention was undertaken in patients involved in this study. Live birth outcomes and clinical pregnancy rates. No significant relationship between paternal BMI and early embryo development was found. However, increased paternal BMI was associated with decreased blastocyst development, clinical pregnancy rates and live birth outcomes. To our knowledge, this is the first report linking increased paternal BMI and clinical pregnancy and live birth rates after ART treatment. Further work to elucidate the mechanisms involved is required.
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