成纤维细胞生长因子
生物
细胞生物学
信号转导
骨形态发生蛋白
遗传学
基因
受体
作者
David M. Ornitz,Pierre J. Marie
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2015-07-15
卷期号:29 (14): 1463-1486
被引量:328
标识
DOI:10.1101/gad.266551.115
摘要
Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored.
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