圆锥角膜
角膜胶原交联
Scheimpflug原理
角膜曲率计
医学
眼科
屈光度
视力
角膜测厚术
角膜上皮
核黄素
前瞻性队列研究
苯扎溴铵
角膜地形图
角膜
外科
病理
化学
生物化学
作者
Zisis Gatzioufas,Frederik Raiskup,David O’Brart,Eberhard Spoerl,Georgios D. Panos,Farhad Hafezi
出处
期刊:Journal of Refractive Surgery
[SLACK, Inc.]
日期:2016-06-01
卷期号:32 (6): 372-377
被引量:40
标识
DOI:10.3928/1081597x-20160428-02
摘要
PURPOSE: To assess the efficacy of a modified high concentration riboflavin solution containing benzalkonium chloride 0.01% for transepithelial corneal cross-linking (CXL). METHODS: In this prospective, interventional multicenter cohort study, 26 eyes of 26 patients with documented progressive keratoconus who underwent transepithelial CXL were included. Follow-up at 6 and 12 months postoperatively included slit-lamp examination, uncorrected and corrected distance visual acuity (logMAR), maximum keratometry (Kmax), and corneal pachymetry (corneal thinnest point) as determined by Scheimpflug imaging. Statistical analysis was performed using repeated measures analysis of variance and the Friedman test for parametric and non-parametric data, respectively. P values less than .05 were considered significant. RESULTS: Kmax did not change significantly at postoperative months 6 and 12. Changes in corneal thinnest point did not change postoperatively over 12 months. Uncorrected and corrected distance visual acuity did not change postoperatively. Progression (defined by an increase in Kmax greater than 1.00 diopter occurred in 46% of eyes at 12 months. Corneal epithelial defects were observed in 46% of the patients and marked punctate corneal epitheliopathy/loose epithelium in 23% of the patients in the immediate postoperative period. No corneal infection, sterile infiltrates, or haze were observed. CONCLUSIONS: Transepithelial CXL with an enhanced riboflavin solution did not effectively halt progression of keratoconus. Significant epithelium damage was evident in the immediate postoperative period. [ J Refract Surg. 2016;32(6):372–377.]
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