楔前
纤维束成像
人脑
磁共振弥散成像
神经科学
连接体
大脑皮层
皮质(解剖学)
心理学
中心性
大脑定位
脑回
中央前回
认知
生物
功能连接
医学
磁共振成像
数学
组合数学
放射科
作者
Chao‐Gan Yan,Gaolang Gong,Jinhui Wang,De‐Yi Wang,Dongqiang Liu,Chaozhe Zhu,Zhang J. Chen,Alan C. Evans,Yu‐Feng Zang,Yong He
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2010-06-18
卷期号:21 (2): 449-458
被引量:255
标识
DOI:10.1093/cercor/bhq111
摘要
The anatomical connectivity of the human cerebral cortex resembles a "small-world" architecture, which is characterized by the coexistence of structurally segregated and integrative connectivity patterns. However, organizational differences in networks among individuals remain largely unknown. Here, we utilize diffusion tensor imaging tractography and graph-theoretical approaches to investigate the effects of sex and brain size on the topological organization of human cortical anatomical network. Weighted cortical networks were constructed from 72 young healthy participants by measuring anatomical connection densities between 78 cortical regions. As expected, all participants showed a small-world topology (high local clustering and short paths between nodes), which suggests a highly efficient topological organization. Furthermore, we found that females had greater local efficiencies than males. Moreover, smaller brains showed higher local efficiency in females but not in males, suggesting an interaction between sex and brain size. Specifically, we show that several brain regions (e.g., the precuneus, precentral gyrus, and lingual gyrus) had significant associations between nodal centrality and sex or brain size. Our findings suggest that anatomical network organization in the human brain is associated with sex and brain size and provide insights into the understanding of the structural substrates that underlie individual differences in behavior and cognition.
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