信号转导
血管紧张素II
细胞生物学
血管平滑肌
细胞内
二酰甘油激酶
生物
受体
磷脂酶C
细胞信号
神经科学
蛋白激酶C
内分泌学
生物化学
平滑肌
作者
Rhian M. Touyz,Ernesto L. Schiffrin
出处
期刊:PubMed
日期:2000-12-01
卷期号:52 (4): 639-72
被引量:908
摘要
Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II (Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways, where intracellular targets of the phospholipase C-diacylglycerol-Ca(2+) axis were distinct from those of the tyrosine kinase- and mitogen-activated protein kinase- dependent pathways. However, these major intracellular signaling cascades do not function independently and are actively engaged in cross-talk. Downstream signals from the Ang II-bound receptors converge to elicit complex and multiple responses. The exact adapter proteins or "go-between" molecules that link the multiple intracellular pathways await clarification. Ang II induces a multitude of actions in various tissues, and the signaling events following occupancy and activation of angiotensin receptors are tightly controlled and extremely complex. Alterations of these highly regulated signaling pathways in vascular smooth cells may be pivotal in structural and functional abnormalities that underlie vascular pathological processes in cardiovascular diseases such as hypertension, atherosclerosis, and post-interventional restenosis.
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