Diagnostic value of serum B7-H4 for hepatocellular carcinoma

医学 危险系数 肝细胞癌 置信区间 内科学 癌症 转移 胃肠病学 肿瘤科 比例危险模型 阶段(地层学) 生物 古生物学
作者
Cheng Zhang,Yiming Li,Yang Wang
出处
期刊:Journal of Surgical Research [Elsevier BV]
卷期号:197 (2): 301-306 被引量:31
标识
DOI:10.1016/j.jss.2015.04.034
摘要

Background Previous studies have suggested the abnormal expression of soluble B7-H4 (sB7-H4) in circulation in cancer patients. The aim of present study was to examine the sB7-H4 expression in serum and to investigate the correlations between sB7-H4 levels and clinicopathologic parameters as well as the survival rate of patients with hepatocellular carcinoma (HCC). Materials and methods Circulating sB7-H4 levels in blood specimens from 93 patients with HCC and 55 healthy volunteers were examined by enzyme-linked immunosorbent assay. The association of sB7-H4 levels with clinicopathologic factors, overall survival (OS), and time to recurrence were statistically analyzed. Results sB7-H4 levels in HCC patients were significantly higher than that in healthy controls (49.12 ± 3.10 versus 31.66 ± 2.59 ng/mL, P < 0.001). High sB7-H4 levels were correlated with tumor size (P = 0.007), tumor invasion (P = 0.037), tumor differentiation (P = 0.044) and tumor-node metastasis stage (P < 0.001). In addition, high sB7-H4 levels were significantly related to poor OS and higher recurrence probability (P = 0.002, P = 0.014, respectively). High sB7-H4 levels were independent prognostic factors for both OS (hazard ratio = 2.497; 95% confidence interval, 1.133–3.789; P = 0.009) and time to recurrence (hazard ratio = 2.33; 95% confidence interval, 1.247–4.179; P = 0.008). Conclusions Detection of sB7-H4 in serum might serve as a clinical predictor in the diagnosis or prediction of clinical outcomes for the patients with HCC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
赵馨儿完成签到,获得积分10
刚刚
ddd发布了新的文献求助10
刚刚
科研小垃圾完成签到,获得积分10
刚刚
龙辉完成签到,获得积分10
刚刚
最後まで发布了新的文献求助10
1秒前
WEI发布了新的文献求助10
1秒前
Rando发布了新的文献求助10
2秒前
JiaxinChen完成签到,获得积分10
2秒前
干净怀寒完成签到,获得积分20
2秒前
酷酷的冰真应助cc采纳,获得20
2秒前
2秒前
2秒前
南国完成签到,获得积分10
2秒前
zy发布了新的文献求助10
3秒前
JCX完成签到,获得积分20
3秒前
dameinv完成签到 ,获得积分10
3秒前
搜集达人应助save采纳,获得10
3秒前
w1完成签到,获得积分10
3秒前
复杂的海完成签到,获得积分10
3秒前
欢喜的小珍完成签到 ,获得积分10
3秒前
愉快的戎完成签到,获得积分10
3秒前
5秒前
Reeee完成签到 ,获得积分10
5秒前
林佳一完成签到,获得积分10
5秒前
沉静的万天完成签到 ,获得积分10
6秒前
6秒前
6秒前
千宝发布了新的文献求助10
6秒前
7秒前
7秒前
DZQ发布了新的文献求助10
7秒前
弦星潺完成签到,获得积分20
7秒前
yy完成签到,获得积分10
8秒前
Gavin完成签到,获得积分10
8秒前
8秒前
有魅力的发卡完成签到,获得积分10
8秒前
8秒前
baozibaozi完成签到,获得积分10
9秒前
李健应助xxxt采纳,获得10
9秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969322
求助须知:如何正确求助?哪些是违规求助? 3514152
关于积分的说明 11172188
捐赠科研通 3249407
什么是DOI,文献DOI怎么找? 1794832
邀请新用户注册赠送积分活动 875437
科研通“疑难数据库(出版商)”最低求助积分说明 804781