孟德尔随机化
甲状旁腺激素
维生素D与神经学
优势比
内科学
内分泌学
医学
阿尔茨海默病
单核苷酸多态性
等位基因
疾病
生物
遗传学
基因型
基因
钙
遗传变异
作者
Susanna C. Larsson,Matthew Traylor,Hugh S. Markus,Karl Michaëlsson
出处
期刊:Nutrients
[MDPI AG]
日期:2018-09-06
卷期号:10 (9): 1243-1243
被引量:28
摘要
We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer’s disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer’s Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97–1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78–0.94; p = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD.
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