脊髓损伤
肌电图
物理医学与康复
医学
脊髓
机动部队招募
刺激
功能性电刺激
神经科学
心理学
内科学
作者
Richard Cheng,Yanan Sui,Dimitry G. Sayenko,Joel W. Burdick
出处
期刊:IEEE Transactions on Neural Systems and Rehabilitation Engineering
[Institute of Electrical and Electronics Engineers]
日期:2019-05-02
卷期号:27 (6): 1331-1340
被引量:17
标识
DOI:10.1109/tnsre.2019.2914433
摘要
Spinal cord stimulation (SCS) has enabled motor recovery in paraplegics with motor complete spinal cord injury (SCI). However, the physiological mechanisms underlying this recovery are unknown. This paper analyzes muscle synergies in two motor complete SCI patients under SCS during standing and compares them with muscle synergies in healthy subjects, in order to help elucidate the mechanisms that enable motor control through SCS. One challenge is that standard muscle synergy extraction algorithms, such as non-negative matrix factorization (NMF), fail when applied to SCI patients under SCS. We develop a new algorithm-rShiftNMF-to extract muscle synergies in these cases. We find muscle synergies extracted by rShiftNMF are significantly better at interpreting electromyography (EMG) activity, and resulting synergy features are more physiologically meaningful. By analyzing muscle synergies from SCI patients and healthy subjects, we find that: 1) SCI patients rely significantly on muscle synergy activation to generate motor activity; 2) interleaving SCS can selectively activate an additional muscle synergy that is critical to SCI standing; and 3) muscle synergies extracted from SCI patients under SCS differ substantially from those extracted from healthy subjects. We provide evidence that after spinal cord injury, SCS influences motor function through muscle synergy activation.
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