基质凝胶
细胞培养
癌症研究
乳腺癌
体外
约15-3
癌症
氯离子通道
上皮
细胞
乳腺
生物
病理
CA15-3号
内科学
医学
细胞生物学
生物化学
遗传学
作者
Achim D. Gruber,Bendicht U. Pauli
出处
期刊:PubMed
日期:1999-11-01
卷期号:59 (21): 5488-91
被引量:96
摘要
The human Ca2+-activated chloride channel-2 (CLCA2) is expressed in normal breast epithelium but not in breast tumors of different stages of progression. Northern analysis of nontransformed and transformed breast epithelial cell lines revealed CLCA2 expression in the nontransformed cell line MCF10A and the nontumorigenic cell line MDA-MB-453, whereas all tumorigenic cell lines were negative (MDA-MB-231, MDA-MB-435, MDA-MB-468, and MCF7). When stably reintroduced into CLCA2-negative MDA-MB-231 and MDA-MB-435 cells, CLCA2 expression reduced Matrigel invasion in vitro and inducibility of s.c. and metastatic tumors of MDA-MB-231 cells in nude mice. Our results suggest that CLCA2 may act as a tumor suppressor in breast cancer.
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