小檗碱
抗菌剂
盐酸小檗碱
化学
抗菌活性
广谱
细菌
组合化学
药理学
医学
有机化学
生物
遗传学
作者
Faisal Jamshaid,Jun Dai,Yang Li
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2020-05-17
卷期号:20 (8): 716-724
被引量:21
标识
DOI:10.2174/1389557520666200103115124
摘要
: Many berberine derivatives have been synthesized for their antibacterial activity in the past years. In order to elucidate their new Structural Activity Relationship (SAR), the recently synthesized berberine derivatives are reviewed. The newly synthesized berberine derivatives are reported in this review with novel modifications on the berberine structure at various positions. It is hoped that this article would help scientists to design and synthesize new berberine derivatives with high potency and a broad spectrum of antimicrobial activities, more effectiveness and lower toxicity for improved antimicrobial therapy. These berberine derivatives could be developed as novel antibacterial agents to treat patients with infectious diseases, especially caused by resistant bacteria.
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