化学
烷基化
催化作用
钪
有机化学
组合化学
药物化学
作者
Jianhong Su,Yanping Cai,Xin Xu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-10-29
卷期号:21 (22): 9055-9059
被引量:33
标识
DOI:10.1021/acs.orglett.9b03451
摘要
An efficient para-alkylation of primary and secondary anilines with a variety of sterically encumbered alkenes using a simple β-diketiminato scandium catalyst is reported. This protocol features 100% atom economy, excellent chemo- and regioselectivity, broad substrate scope, and good functional group tolerance. Mechanistic studies disclosed that the reaction probably proceeded via a tandem hydroamination/Hofmann-Martius rearrangement.
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