药物输送
零阶
零价铁
材料科学
药品
环糊精
零(语言学)
化学工程
纳米技术
组合化学
一级
物理化学
色谱法
化学
药理学
应用数学
数学
医学
吸附
工程类
语言学
哲学
作者
Yanyi Li,Haobin Huang,Chong-Wei Ding,Xiao‐Ping Zhou,Hong Li
标识
DOI:10.1016/j.matlet.2021.129766
摘要
A zero-order drug delivery system (DDS) is one of the most critical strategies in pharmaceutical technology. Herein, β-cyclodextrins-based metal–organic framework (CD-MOF) with double channel structures was obtained, which was used as a zero-order DDS for loading naringin (NAR). The drug release with a zero-order kinetic rule was observed over 30 days; while a high entrapment efficiency of over 80% was obtained. No negative effect was detected when NAR/CD-MOF co-cultured with MC3T3-E1 cells. Hence, CD-MOF would be a potential carrier for zero-order DDSs.
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