少突胶质细胞
棕榈酰化
生物
细胞生物学
蛋白脂蛋白1
髓鞘碱性蛋白
神经科学
髓鞘
中枢神经系统
生物化学
半胱氨酸
酶
作者
Yanchen Ma,Huiqing Liu,Zhimin Ou,Qi Chen,Rui Xing,Shiyun Wang,Yinuo Han,Tong‐Jin Zhao,Ying Chen
出处
期刊:Glia
[Wiley]
日期:2021-11-01
卷期号:70 (2): 379-392
被引量:11
摘要
Myelin sheath is an important structure to maintain functions of the nerves in central nervous system. Protein palmitoylation has been established as a sorting determinant for the transport of myelin-forming proteins to the myelin membrane, however, its function in the regulation of oligodendrocyte development remains unknown. Here, we show that an Asp-His-His-Cys (DHHC) motif-containing palmitoyl acyltransferases, DHHC5, is involved in the control of oligodendrocyte development. Loss of Zdhhc5 in oligodendrocytes inhibits myelination and remyelination by reducing total myelinating oligodendrocyte population. STAT3 is the primary substrate for DHHC5 palmitoylation in oligodendrocytes. Zdhhc5 ablation reduces STAT3 palmitoylation and suppresses STAT3 phosphorylation and activation. As a result, the transcription of the myelin-related and anti-apoptosis genes is inhibited, leading to suppressed oligodendrocyte development and myelination. Our findings demonstrate a key role DHHC5 in controlling myelinogenesis.
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