生物膜
纳米反应器
两亲性
纳米载体
葡萄糖氧化酶
材料科学
组合化学
水溶液
纳米技术
催化作用
自组装
药物输送
细菌
纳米颗粒
化学
有机化学
生物传感器
生物
共聚物
复合材料
遗传学
聚合物
作者
Yuting Shi,Yufei Cao,Ju Cheng,Wenwen Yu,Mingsheng Liu,Juanjuan Yin,Congshu Huang,Xiaoqin Liang,Haicun Zhou,Hongbin Liu,Zheng Yang,Fang Yu,Hua Wei,Guanghui Zhao
标识
DOI:10.1002/adfm.202111148
摘要
Abstract The traditional treatment for bacterial infections is the use of antibiotics, but the overuse of antibiotics can lead to the formation of multidrug‐resistant bacteria, and eventually lead to the formation of biofilms, which can resist the attack of the host immune system and the penetration of antibiotics in biofilms. Although biofilm‐targeted and stimulus‐responsive antibiotic delivery nanocarriers are available, the drugs that can be delivered is extremely limited. Therefore, an amphiphilic supramolecule Arg‐CD‐AcMH is constructed via host–guest interactions between β‐CD‐terminated arginine (Arg‐CD) and ferrocene‐terminated acetal‐modified maltoheptaose. The amphiphilic supramolecule Arg‐CD‐AcMH can self‐assemble with glucoamylase and glucose oxidase in aqueous solution to form spherical nanoparticles through hydrophilic–hydrophobic and electrostatic interactions. These nanoparticles can respond to the micro‐environment in the biofilm and selectively increase the level of H 2 O 2 in the biofilm through the cascading catalytic effect of enzymes based on the self‐supply glucose, thus providing conditions for the release of anti‐biofilm active drug nitric oxide.
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