生物能学
糖酵解
合成代谢
电子传输链
癌症
线粒体
癌细胞
生物
细胞生物学
生物信息学
氧化磷酸化
化学
生物化学
新陈代谢
遗传学
作者
John Greene,Ashvina Segaran,Simon Lord
标识
DOI:10.1016/j.semcancer.2022.02.002
摘要
Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation of ATP but it is now clear that OXPHOS, at least in many tumour types, plays a critical role in delivering the bioenergetic and macromolecular anabolic requirements of cancer cells. There is now great interest in targeting the OXPHOS and the electron transport chain for cancer therapy and in this review article we describe current therapeutic approaches and challenges.
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