Bonsai-inspired AIE nanohybrid photosensitizer based on vermiculite nanosheets for ferroptosis-assisted oxygen self-sufficient photodynamic cancer therapy

Oxygen-dependent photodynamic therapy (PDT) for cancer treatment based on aggregation-induced emission luminogen (AIEgen) photosensitizer shows limited efficiency in the hypoxic tumor microenvironment (TME). To overcome tumor hypoxia-induced PDT resistance, a bonsai-inspired oxygen self-sufficient photodynamic cancer therapeutic system was developed based on AIEgen/vermiculite nanohybrid. Ultrathin nanosheets (NSs) were synthesized by lithium-ion intercalation from potting soil vermiculite for AIEgen photosensitizer (DCPy) loading through electrostatic attraction to produce [email protected] (nano bonsai). When [email protected] was absorbed by hypoxic the tumor and exposed to white light radiation, the [email protected] could not only produce 1O2 and·OH but also catalyze the H2O2 to generate O2 for alleviating hypoxia significantly improving PDT efficacy. Surprisingly, [email protected] could induce ferroptosis of the tumor by iron overload and depleting glutathione (GSH). Therefore, we provide a bonsai-inspired AIEgen-vermiculite nanohybrid platform for ferroptosis-assisted oxygen self-sufficient photodynamic cancer therapy.