人血清白蛋白
化学
药代动力学
白蛋白
脂肪酸
血清白蛋白
共轭体系
人血浆
血浆蛋白结合
小分子
生物化学
药理学
计算生物学
医学
生物
色谱法
有机化学
聚合物
作者
Sara Linciano,Giulia Moro,Alessandro Zorzi,Alessandro Angelini
标识
DOI:10.1016/j.jconrel.2022.05.038
摘要
Human serum albumin (hSA) is the major carrier protein for fatty acids (FAs) in plasma. Its ability to bind multiple FA moieties with moderate to high affinity has inspired the use of FA conjugation as a safe and natural platform to generate long-lasting therapeutics with enhanced pharmacokinetic properties and superior efficacy. In this frame, the choice of the FA is crucial and a comprehensive elucidation of the molecular interactions of FAs with hSA cannot be left out of consideration. To this intent, we report here a comparative analysis of the binding mode of different FA moieties with hSA. The choice among different albumin-binding FAs and how this influence the pharmacokinetics properties of a broad spectrum of therapeutic molecules will be discussed including a critical description of some clinically relevant FA conjugated therapeutics.
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