Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner

医学 品味 减肥 肥胖 胃旁路手术 内科学 方差分析 食物偏好 胃肠病学 胃分流术 食品科学 生物
作者
Madhawi Aldhwayan,Werd Al‐Najim,Aruchuna Ruban,Michael A. Glaysher,Brett Johnson,Navpreet Chhina,Georgios K. Dimitriadis,Christina Prechtl,Nicholas Johnson,James Byrne,Anthony P. Goldstone,Julian Teare,Carel W. le Roux,Alexander D. Miras
出处
期刊:Nutrients [MDPI AG]
卷期号:14 (10): 2141-2141 被引量:4
标识
DOI:10.3390/nu14102141
摘要

The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist approach to determine whether bypass of the proximal intestine is the component conferring the effects of RYGB on food intake and sweet taste preference using the Endobarrier as a research tool. A nested mechanistic study within a large randomised controlled trial compared the impact of lifestyle modification with vs. without Endobarrier insertion in patients with obesity and T2DM. Forty-seven participants were randomised and assessed at several timepoints using direct and indirect assessments of food intake, food preference and taste function. Patients within the Endobarrier group lost numerically more weight compared to the control group. Using food diaries, our results demonstrated similar reductions of food intake in both groups. There were no significant differences in food preference and sensory, appetitive reward, or consummatory reward domain of sweet taste function between groups or changes within groups. In conclusion, the superior weight loss seen in patients with obesity and T2DM who underwent the Endobarrier insertion was not due to a reduction in energy intake or change in food preferences.
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