程序性细胞死亡
生物
细胞生物学
活性氧
GPX4
氧化应激
拟南芥
抗坏血酸
拟南芥
胞浆
谷胱甘肽
热休克蛋白
热冲击
细胞
细胞凋亡
生物化学
突变体
谷胱甘肽过氧化物酶
酶
过氧化氢酶
基因
食品科学
作者
Ayelén Mariana Distéfano,María Victoria Martin,Juan Pablo Córdoba,Andrés Martín Bellido,Sebastián D’Ippólito,Silvana Lorena Colman,Débora Soto,Juan Alfredo Roldán,Carlos Guillermo Bártoli,Eduardo Zabaleta,Diego Fernando Fiol,Brent R. Stockwell,Scott J. Dixon,Gabriela Carolina Pagnussat
标识
DOI:10.1083/jcb.201605110
摘要
In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)–induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient.
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