Amidyl Radical Directed γ‐C(sp3)−H Functionalization with Silyl Enol Ethers via Photoredox Catalysis

Abstract Herein we reported an efficient photoredox‐catalyzed reaction for site‐selective C(sp 3 )−H functionalization of carboxamides with silyl enol ethers as radical acceptors. The reaction proceeded through amidyl radical‐directed 1,5‐hydrogen atom transfer (1,5‐HAT) and C(sp 3 )−C(sp 3 ) bond formation via radical addition of silyl enol ethers. The process features mild conditions and high functional‐group tolerance, allowing the preparation of a series of carboxamides with pendant carbonyl moieties.