A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis

心脏毒性 双金属片 药理学 化学 阿霉素 氧化应激 抗氧化剂 癌症研究 医学 化疗 生物化学 内科学 催化作用
作者
Junyue Xing,Xiaohan Ma,Yanan Yu,Yangfan Xiao,Lu Chen,Wenhua Yuan,Yingying Wang,Keyu Liu,Guo Zhiping,Hao Tang,Kelong Fan,Wei Jiang
出处
期刊:Advanced Science [Wiley]
标识
DOI:10.1002/advs.202405597
摘要

Abstract Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated a strong correlation between DOX‐induced cardiotoxicity and the activation of oxidative stress pathways. This work introduces a novel antioxidant therapeutic approach, utilizing libraries of tannic acid and N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme‐like activity, an optimal bimetallic nanozyme (AuRu) is identified that possess remarkable antioxidant characteristics, mimicking catalase‐like enzymes. Theoretical calculations reveal the surface interactions of the prepared nanozymes that simulate the hydrogen peroxide decomposition process, showing that these bimetallic nanozymes readily undergo OH⁻ adsorption and O₂ desorption. To enhance cardiac targeting, the atrial natriuretic peptide is conjugated to the AuRu nanozyme. These cardiac‐targeted bimetallic cluster nanozymes, with their anchoring capability, effectively reduce DOX‐induced cardiomyocyte ferroptosis and PANoptosis without compromising tumor treatment efficacy. Thus, the therapeutic approach demonstrates significant reductions in chemotherapy‐induced cardiac cell death and improvements in cardiac function, accompanied by exceptional in vivo biocompatibility and stability. This study presents a promising avenue for preventing chemotherapy‐induced cardiotoxicity, offering potential clinical benefits for cancer patients.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
今后应助夏果果采纳,获得10
刚刚
生椰拿铁不加生椰完成签到 ,获得积分10
1秒前
2秒前
小虫发布了新的文献求助10
3秒前
周慧玲完成签到 ,获得积分10
3秒前
专注的草丛完成签到,获得积分10
4秒前
4秒前
孤巷的猫完成签到,获得积分10
4秒前
顾矜应助Ting采纳,获得10
5秒前
cqyyy完成签到 ,获得积分10
6秒前
李杰发布了新的文献求助10
6秒前
Cat应助胡豆豆采纳,获得20
7秒前
水若琳完成签到,获得积分10
8秒前
9秒前
9秒前
9秒前
平淡问雁完成签到,获得积分10
12秒前
13秒前
科研通AI2S应助Yara.H采纳,获得10
13秒前
外向语山发布了新的文献求助10
13秒前
15秒前
炙热冰夏发布了新的文献求助10
15秒前
忧郁绝音发布了新的文献求助10
16秒前
桐桐应助羊羊采纳,获得10
17秒前
梧桐断角发布了新的文献求助10
17秒前
ding应助科研通管家采纳,获得10
20秒前
20秒前
20秒前
科研通AI2S应助科研通管家采纳,获得30
20秒前
ziyue应助科研通管家采纳,获得10
20秒前
爆米花应助科研通管家采纳,获得10
20秒前
科研通AI2S应助科研通管家采纳,获得10
21秒前
21秒前
嗯哼应助科研通管家采纳,获得20
21秒前
21秒前
隐形曼青应助科研通管家采纳,获得10
21秒前
上官若男应助科研通管家采纳,获得10
21秒前
情怀应助科研通管家采纳,获得10
21秒前
Zkxxxx发布了新的文献求助10
21秒前
悦己完成签到,获得积分10
21秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
CLSI EP47 Evaluation of Reagent Carryover Effects on Test Results, 1st Edition 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3055485
求助须知:如何正确求助?哪些是违规求助? 2712292
关于积分的说明 7430453
捐赠科研通 2357116
什么是DOI,文献DOI怎么找? 1248604
科研通“疑难数据库(出版商)”最低求助积分说明 606750
版权声明 596093