免疫刺激剂
免疫疗法
内质网
肽
癌症研究
医学
化学
免疫学
免疫系统
生物化学
作者
Rongrong Zheng,Yang Ni,Qiuyuan Li,Zuxiao Chen,Chu‐Yu Huang,Linping Zhao,Xin Chen,Shiying Li
出处
期刊:PubMed
日期:2024-08-14
标识
DOI:10.1016/j.jconrel.2024.08.013
摘要
The combination of therapy-induced immunogenic cell death (ICD) and immune checkpoint blockade can provide a mutually reinforced strategy to reverse the poor immunogenicity and immune escape behavior of tumors. In this work, a chimeric peptide-engineered immunostimulant (ER-PPB) is fabricated for endoplasmic reticulum (ER)-targeted photodynamic immunotherapy against metastatic tumors. Among which, the amphiphilic chimeric peptide (ER-PP) is composed of ER-targeting peptide FFKDEL, hydrophilic PEG
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