Asymmetric transformations enabled by synergistic dual transition-metal catalysis

From its beginnings in the Sonogashira reaction, synergistic dual transition-metal catalysis has gained increasing prominence and importance. In the past decade, this strategy has been intensively investigated in the enantioselective construction of chemical bonds and has shown an increasing number of novel transformations and yielded greater reactivity, selectivity, and efficiency than traditional mono-transition-metal catalysis. In this review, we present recent examples of asymmetric reactions enabled by synergistic dual metal catalysis to provide readers with the fundamental attributes and abilities of this concept. We discuss the mechanism, kinetics, and selectivity in detail to showcase how two distinct transition-metal complexes would work cooperatively and independently to enable challenging transformations.