偏头痛
医学
全基因组关联研究
甲状腺功能
内科学
甲状腺
遗传关联
内分泌学
遗传学
基因
单核苷酸多态性
生物
基因型
作者
Sana Tasnim,Scott G. Wilson,John P. Walsh,Dale R. Nyholt
出处
期刊:Cephalalgia
[SAGE]
日期:2023-02-01
卷期号:43 (2): 033310242211392-033310242211392
被引量:8
标识
DOI:10.1177/03331024221139253
摘要
Background Epidemiological studies have reported a comorbid relationship between migraine and thyroid dysfunction. Methods We investigated the genetic relationship between migraine and thyroid function traits using genome-wide association study (GWAS) data. Results We found a significant genetic correlation ( r g ) with migraine for hypothyroidism ( r g = 0.0608), secondary hypothyroidism ( r g = 0.195), free thyroxine (fT4) ( r g = 0.0772), and hyperthyroidism ( r g = –0.1046), but not thyroid stimulating hormone (TSH). Pairwise GWAS analysis revealed two shared loci with TSH and 11 shared loci with fT4. Cross-trait GWAS meta-analysis of migraine identified novel genome-wide significant loci: 17 with hypothyroidism, one with hyperthyroidism, five with secondary hypothyroidism, eight with TSH, and 15 with fT4. Of the genes at these loci, six ( RERE, TGFB2, APLF, SLC9B1, SGTB, BTBD16; migraine + hypothyroidism), three ( GADD45A, PFDN1, RSPH6A; migraine + TSH), and three ( SSBP3, BRD3, TEF; migraine + fT4) were significant in our gene-based analysis ( p Fisher’s combined P-value < 2.04 × 10 −6 ). In addition, causal analyses suggested a negative causal relationship between migraine and hyperthyroidism ( p = 8.90 × 10 −3 ) and a positive causal relationship between migraine and secondary hypothyroidism ( p = 1.30 × 10 −3 ). Conclusion These findings provide strong evidence for genetic correlation and suggest complex causal relationships between migraine and thyroid traits.
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