化学
达布科
催化作用
辛烷值
光激发
肟
组合化学
激进的
接受者
光化学
有机化学
物理
核物理学
激发态
凝聚态物理
作者
Xiaolong Huang,Dong‐Liang Zhang,Qing Li,Zongbo Xie,Zhanggao Le,Zhiqiang Zhu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-04-28
卷期号:26 (18): 3727-3732
标识
DOI:10.1021/acs.orglett.4c00742
摘要
Photoexcitation electron donor–acceptor (EDA) complexes provide an effective approach to produce radicals under mild conditions, while the catalytic version of EDA complex photoactivation remains scarce. Herein, we report a visible-light-induced organophotocatalytic pathway for the cyanoalkylation of azauracils using inexpensive and readily available 1,4-diazabicyclo[2.2.2]octane (DABCO) as a catalytic electron donor. This synthetic method exhibits exceptional compatibility with various functional groups and presents 34 examples in high yields. The efficient cyanoalkylation offers an environmentally friendly and sustainable route toward enhancing the structural and functional diversity of azauracils.
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