类有机物
诱导多能干细胞
镜像
生物
干细胞
心脏发育
人的心脏
人诱导多能干细胞
细胞生物学
计算生物学
神经科学
医学
内科学
胚胎干细胞
遗传学
心理学
基因
沟通
作者
Brett Volmert,Aitor Aguirre
标识
DOI:10.1007/7651_2024_545
摘要
Organoids derived from pluripotent stem cells exhibit notable similarities to organ development in vitro. Nonetheless, cardiac organoids generated to date possess immature phenotypes and are unable to model the full spectrum of heart development and disease. Here, we describe the developmental maturation of human heart organoids by controlled exposure to metabolic and hormonal factors over a 10-day period, mirroring key stages of human cardiac development and resulting in significant molecular, cellular, morphological, and functional changes. Overall, our findings represent a significant advancement in synthetic human heart development, offering a valuable platform for studying cardiac disease states and conducting pharmacological research.
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