置信区间
医学
优势比
眼底(子宫)
眼科
前瞻性队列研究
内科学
作者
Ruoyan Wei,Jun Li,Weiming Yang,Chang Liu,Yunzhe Wang,Lin Wang,Shixue Liu,Yongfu Yu,Chen Huang,Ke-Wei Song,Lie Ju,Wanji He,Hua Zhong,Yanting Pan,Feiyan Fu,Xiaoying Wang,Yuzhong Chen,Zongyuan Ge,Mingguang He,Xingtao Zhou,Meiyan Li
出处
期刊:Retina-the Journal of Retinal and Vitreous Diseases
[Ovid Technologies (Wolters Kluwer)]
日期:2024-03-01
卷期号:44 (3): 527-536
标识
DOI:10.1097/iae.0000000000003991
摘要
Purpose: To investigate fundus tessellation density (TD) and its association with axial length (AL) elongation and spherical equivalent (SE) progression in children. Methods: The school-based prospective cohort study enrolled 1,997 individuals aged 7 to 9 years in 11 elementary schools in Mojiang, China. Cycloplegic refraction and biometry were performed at baseline and 4-year visits. The baseline fundus photographs were taken, and TD, defined as the percentage of exposed choroidal vessel area in the photographs, was quantified using an artificial intelligence–assisted semiautomatic labeling approach. After the exclusion of 330 ineligible participants because of loss to follow-up or ineligible fundus photographs, logistic models were used to assess the association of TD with rapid AL elongation (>0.36 mm/year) and SE progression (>1.00 D/year). Results: The prevalence of tessellation was 477 of 1,667 (28.6%) and mean TD was 0.008 ± 0.019. The mean AL elongation and SE progression in 4 years were 0.90 ± 0.58 mm and −1.09 ± 1.25 D. Higher TD was associated with longer baseline AL (β, 0.030; 95% confidence interval: 0.015–0.046; P < 0.001) and more myopic baseline SE (β, −0.017; 95% confidence interval: −0.032 to −0.002; P = 0.029). Higher TD was associated with rapid AL elongation (odds ratio, 1.128; 95% confidence interval: 1.055–1.207; P < 0.001) and SE progression (odds ratio, 1.123; 95% confidence interval: 1.020–1.237; P = 0.018). Conclusion: Tessellation density is a potential indicator of rapid AL elongation and refractive progression in children. TD measurement could be a routine to monitor AL elongation.
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