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Altered resting-state brain oscillation and the associated cognitive impairments in late-life depression with different depressive severity: An EEG power spectrum and functional connectivity study

功能连接 心理学 认知 静息状态功能磁共振成像 脑电图 听力学 萧条(经济学) 神经科学 医学 经济 宏观经济学
作者
Yijie Zeng,Jingyi Lao,Zhangying Wu,Gaohong Lin,Qiang Wang,Mingfeng Yang,Si Zhang,Danyan Xu,Min Zhang,Shuang Liang,Qin Liu,Kexin Yao,Jiafu Li,Yuping Ning,Xiaomei Zhong
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:348: 124-134 被引量:7
标识
DOI:10.1016/j.jad.2023.10.157
摘要

Cognitive impairments are prevalent in late-life depression (LLD). However, it remains unclear whether there are concurrent brain oscillation alterations in resting condition across varying level of depression severity. This cross-sectional study aims to investigate the characteristics of altered resting-state oscillations, including power spectrum and functional connectivity, and their association with the cognitive impairments in LLD with different depression severity. A total of 65 patients with LLD and 40 elder participants without depression were recruited. Global cognition and subtle cognitive domains were evaluated. A five-minute resting-state electroencephalography (EEG) was conducted under eyes-closed conditions. Measurements included the ln-transformed absolute power for power spectrum analysis and the weighted phase lag index (wPLI) for functional connectivity analysis. Attentional and executive dysfunction were exhibited in Moderate-Severe LLD group. Enhanced posterior upper gamma power was observed in both LLD groups. Additionally, enhanced parietal and fronto-parietal/occipital theta connectivity were observed in Moderate-Severe LLD group, which were associated with the attentional impairment. Limitations include a small sample size, concomitant medication use, and a relatively higher proportion of females. Current study observed aberrant brain activity patterns in LLD across different levels of depression severity, which were linked to cognitive impairments. The altered posterior brain oscillations may be trait marker of LLD. Moreover, cognitive impairments and associated connectivity alterations were exhibited in moderate-severe group, which may be a state-like marker of moderate-to severe LLD. The study deepens understanding of cognitive impairments with the associated oscillation changes, carrying implications for neuromodulation targets in LLD.
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